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Grandilodines A—C, Biologically active indole alkaloids from kopsia grandifolia

Three new indole alkaloids (1—3), named grandilodines A—C, and five known ones were obtained from the Malayan Kopsia grandifolia. The structures were established usingNMRand MS analyses and, in the case of 1 and 2, were confirmed by X-ray diffraction analyses. Alkaloids 1, 3, and lapidilectine B (8...

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Main Authors: Kam, T.S., Yap, W.S., Gan, C.Y., Low, Y.Y., Choo, Y.M., Etoh, T., Hayashi, M., Komiyama, K.
Format: Article
Language:English
Published: American Chemical Society and American Society of Pharmacognosy 2011
Subjects:
QD Chemistry
Online Access:http://eprints.um.edu.my/10390/1/Grandilodines_A%E2%80%94C%2C_Biologically_Active_Indole_Alkaloids_from_Kopsia_grandifolia.pdf
http://eprints.um.edu.my/10390/
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spelling my.um.eprints.103902014-10-15T01:53:04Z http://eprints.um.edu.my/10390/ Grandilodines A—C, Biologically active indole alkaloids from kopsia grandifolia Kam, T.S. Yap, W.S. Gan, C.Y. Low, Y.Y. Choo, Y.M. Etoh, T. Hayashi, M. Komiyama, K. QD Chemistry Three new indole alkaloids (1—3), named grandilodines A—C, and five known ones were obtained from the Malayan Kopsia grandifolia. The structures were established usingNMRand MS analyses and, in the case of 1 and 2, were confirmed by X-ray diffraction analyses. Alkaloids 1, 3, and lapidilectine B (8) were found to reverse multidrug resistance in vincristine-resistant KB cells. American Chemical Society and American Society of Pharmacognosy 2011 Article PeerReviewed application/pdf en http://eprints.um.edu.my/10390/1/Grandilodines_A%E2%80%94C%2C_Biologically_Active_Indole_Alkaloids_from_Kopsia_grandifolia.pdf Kam, T.S. and Yap, W.S. and Gan, C.Y. and Low, Y.Y. and Choo, Y.M. and Etoh, T. and Hayashi, M. and Komiyama, K. (2011) Grandilodines A—C, Biologically active indole alkaloids from kopsia grandifolia. Journal of Natural Products, 74. pp. 1309-1312. ISSN 0163-3864 DOI: 10.1021/np200008g
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
language English
topic QD Chemistry
spellingShingle QD Chemistry
Kam, T.S.
Yap, W.S.
Gan, C.Y.
Low, Y.Y.
Choo, Y.M.
Etoh, T.
Hayashi, M.
Komiyama, K.
Grandilodines A—C, Biologically active indole alkaloids from kopsia grandifolia
description Three new indole alkaloids (1—3), named grandilodines A—C, and five known ones were obtained from the Malayan Kopsia grandifolia. The structures were established usingNMRand MS analyses and, in the case of 1 and 2, were confirmed by X-ray diffraction analyses. Alkaloids 1, 3, and lapidilectine B (8) were found to reverse multidrug resistance in vincristine-resistant KB cells.
format Article
author Kam, T.S.
Yap, W.S.
Gan, C.Y.
Low, Y.Y.
Choo, Y.M.
Etoh, T.
Hayashi, M.
Komiyama, K.
author_facet Kam, T.S.
Yap, W.S.
Gan, C.Y.
Low, Y.Y.
Choo, Y.M.
Etoh, T.
Hayashi, M.
Komiyama, K.
author_sort Kam, T.S.
title Grandilodines A—C, Biologically active indole alkaloids from kopsia grandifolia
title_short Grandilodines A—C, Biologically active indole alkaloids from kopsia grandifolia
title_full Grandilodines A—C, Biologically active indole alkaloids from kopsia grandifolia
title_fullStr Grandilodines A—C, Biologically active indole alkaloids from kopsia grandifolia
title_full_unstemmed Grandilodines A—C, Biologically active indole alkaloids from kopsia grandifolia
title_sort grandilodines a—c, biologically active indole alkaloids from kopsia grandifolia
publisher American Chemical Society and American Society of Pharmacognosy
publishDate 2011
url http://eprints.um.edu.my/10390/1/Grandilodines_A%E2%80%94C%2C_Biologically_Active_Indole_Alkaloids_from_Kopsia_grandifolia.pdf
http://eprints.um.edu.my/10390/
_version_ 1643688787344097280
score 13.214096

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