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Grandilodines A—C, Biologically active indole alkaloids from kopsia grandifolia

Three new indole alkaloids (1—3), named grandilodines A—C, and five known ones were obtained from the Malayan Kopsia grandifolia. The structures were established usingNMRand MS analyses and, in the case of 1 and 2, were confirmed by X-ray diffraction analyses. Alkaloids 1, 3, and lapidilectine B (8...

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Bibliographic Details
Main Authors: Kam, T.S., Yap, W.S., Gan, C.Y., Low, Y.Y., Choo, Y.M., Etoh, T., Hayashi, M., Komiyama, K.
Format: Article
Language:English
Published: American Chemical Society and American Society of Pharmacognosy 2011
Subjects:
QD Chemistry
Online Access:http://eprints.um.edu.my/10390/1/Grandilodines_A%E2%80%94C%2C_Biologically_Active_Indole_Alkaloids_from_Kopsia_grandifolia.pdf
http://eprints.um.edu.my/10390/
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Summary:Three new indole alkaloids (1—3), named grandilodines A—C, and five known ones were obtained from the Malayan Kopsia grandifolia. The structures were established usingNMRand MS analyses and, in the case of 1 and 2, were confirmed by X-ray diffraction analyses. Alkaloids 1, 3, and lapidilectine B (8) were found to reverse multidrug resistance in vincristine-resistant KB cells.

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