Targeted drug delivery to the brain via intranasal nanoemulsion: available proof of concept and existing challenges
Intranasal delivery has shown to circumvent blood-brain-barrier (BBB) and deliver the drugs into the CNS at a higher rate and extent than other conventional routes. The mechanism of drug transport from nose-to-brain is not fully understood yet, but several neuronal pathways are considered to be invo...
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10.1016/j.ijpharm.2019.05.032
2019
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my.iium.irep.798092020-03-24T15:08:07Z http://irep.iium.edu.my/79809/ Targeted drug delivery to the brain via intranasal nanoemulsion: available proof of concept and existing challenges Chatterjee, Bappaditya Gorain, Bapi Mohananaidu, Keithanchali Sengupta, Pinaki Ranjan Mandal, Uttam Kumar Choudhury, Hira RS192 Materia Medica-Pharmaceutical Technology Intranasal delivery has shown to circumvent blood-brain-barrier (BBB) and deliver the drugs into the CNS at a higher rate and extent than other conventional routes. The mechanism of drug transport from nose-to-brain is not fully understood yet, but several neuronal pathways are considered to be involved. Intranasal nanoemulsion for brain targeting is investigated extensively. Higher brain distribution of drug after administering intranasal nanoemulsion was established by many researchers. Issues with nasomucosal clearance are solved by formulating modified nanoemulsion; for instance, mucoadhesive nanoemulsion or in situ nanoemulgel. However, no intranasal nanoemulsion for brain targeted drug delivery has been able to cross the way from ‘benches to bed-side’ of patients. Possibilities of toxicity by repeated administration, irregular nasal absorption during the diseased condition, use of a high amount of surfactants are few of the persisting challenges that need to overcome in coming days. Understanding the ways how current developments has solved some challenges is necessary. At the same time, the future direction of the research on intranasal nanoemulsion should be figured out based on existing challenges. This review is focused on the current developments of intranasal nanoemulsion with special emphasis on the existing challenges that would help to set future research direction. 10.1016/j.ijpharm.2019.05.032 2019-06-30 Article PeerReviewed application/pdf en http://irep.iium.edu.my/79809/1/79809_Targeted%20drug%20delivery.pdf application/pdf en http://irep.iium.edu.my/79809/2/79809_Targeted%20drug%20delivery_SCOPUS.pdf application/pdf en http://irep.iium.edu.my/79809/3/79809_Targeted%20drug%20delivery_WOS.pdf Chatterjee, Bappaditya and Gorain, Bapi and Mohananaidu, Keithanchali and Sengupta, Pinaki Ranjan and Mandal, Uttam Kumar and Choudhury, Hira (2019) Targeted drug delivery to the brain via intranasal nanoemulsion: available proof of concept and existing challenges. International Journal of Pharmaceutics, 565. pp. 258-268. ISSN 0378-5173 E-ISSN 1873-3476 https://www.sciencedirect.com/science/article/pii/S0378517319303862?via%3Dihub#! |
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RS192 Materia Medica-Pharmaceutical Technology Chatterjee, Bappaditya Gorain, Bapi Mohananaidu, Keithanchali Sengupta, Pinaki Ranjan Mandal, Uttam Kumar Choudhury, Hira Targeted drug delivery to the brain via intranasal nanoemulsion: available proof of concept and existing challenges |
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Intranasal delivery has shown to circumvent blood-brain-barrier (BBB) and deliver the drugs into the CNS at a higher rate and extent than other conventional routes. The mechanism of drug transport from nose-to-brain is not fully understood yet, but several neuronal pathways are considered to be involved. Intranasal nanoemulsion for brain targeting is investigated extensively. Higher brain distribution of drug after administering intranasal nanoemulsion was established by many researchers. Issues with nasomucosal clearance are solved by formulating modified nanoemulsion; for instance, mucoadhesive nanoemulsion or in situ nanoemulgel. However, no intranasal nanoemulsion for brain targeted drug delivery has been able to cross the way from ‘benches to bed-side’ of patients. Possibilities of toxicity by repeated administration, irregular nasal absorption during the diseased condition, use of a high amount of surfactants are few of the persisting challenges that need to overcome in coming days. Understanding the ways how current developments has solved some challenges is necessary. At the same time, the future direction of the research on intranasal nanoemulsion should be figured out based on existing challenges. This review is focused on the current developments of intranasal nanoemulsion with special emphasis on the existing challenges that would help to set future research direction. |
format |
Article |
author |
Chatterjee, Bappaditya Gorain, Bapi Mohananaidu, Keithanchali Sengupta, Pinaki Ranjan Mandal, Uttam Kumar Choudhury, Hira |
author_facet |
Chatterjee, Bappaditya Gorain, Bapi Mohananaidu, Keithanchali Sengupta, Pinaki Ranjan Mandal, Uttam Kumar Choudhury, Hira |
author_sort |
Chatterjee, Bappaditya |
title |
Targeted drug delivery to the brain via intranasal nanoemulsion: available proof of concept and existing challenges |
title_short |
Targeted drug delivery to the brain via intranasal nanoemulsion: available proof of concept and existing challenges |
title_full |
Targeted drug delivery to the brain via intranasal nanoemulsion: available proof of concept and existing challenges |
title_fullStr |
Targeted drug delivery to the brain via intranasal nanoemulsion: available proof of concept and existing challenges |
title_full_unstemmed |
Targeted drug delivery to the brain via intranasal nanoemulsion: available proof of concept and existing challenges |
title_sort |
targeted drug delivery to the brain via intranasal nanoemulsion: available proof of concept and existing challenges |
publisher |
10.1016/j.ijpharm.2019.05.032 |
publishDate |
2019 |
url |
http://irep.iium.edu.my/79809/1/79809_Targeted%20drug%20delivery.pdf http://irep.iium.edu.my/79809/2/79809_Targeted%20drug%20delivery_SCOPUS.pdf http://irep.iium.edu.my/79809/3/79809_Targeted%20drug%20delivery_WOS.pdf http://irep.iium.edu.my/79809/ https://www.sciencedirect.com/science/article/pii/S0378517319303862?via%3Dihub#! |
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