Targeted drug delivery to the brain via intranasal nanoemulsion: available proof of concept and existing challenges

• Main Authors: Chatterjee, Bappaditya, Gorain, Bapi, Mohananaidu, Keithanchali, Sengupta, Pinaki Ranjan, Mandal, Uttam Kumar, Choudhury, Hira
• Format: Article
• Language: English; English; English
• Published: 10.1016/j.ijpharm.2019.05.032 2019
• Subjects: RS192 Materia Medica-Pharmaceutical Technology
• Online Access: http://irep.iium.edu.my/79809/1/79809_Targeted%20drug%20delivery.pdf; http://irep.iium.edu.my/79809/2/79809_Targeted%20drug%20delivery_SCOPUS.pdf; http://irep.iium.edu.my/79809/3/79809_Targeted%20drug%20delivery_WOS.pdf; http://irep.iium.edu.my/79809/; https://www.sciencedirect.com/science/article/pii/S0378517319303862?via%3Dihub#!

Intranasal delivery has shown to circumvent blood-brain-barrier (BBB) and deliver the drugs into the CNS at a higher rate and extent than other conventional routes. The mechanism of drug transport from nose-to-brain is not fully understood yet, but several neuronal pathways are considered to be invo...