Transdermal delivery of raloxifene HCl via ethosomal system: Formulation, advanced characterizations and pharmacokinetic evaluation

• Main Authors: Mahmood, Syed, Mandal, Uttam Kumar, Chatterjee, Bappaditya
• Format: Article
• Language: English; English; English
• Published: Elsevier B.V. 2018
• Subjects: RS192 Materia Medica-Pharmaceutical Technology
• Online Access: http://irep.iium.edu.my/63349/1/63349_Transdermal%20delivery%20of%20raloxifene%20HCl.pdf; http://irep.iium.edu.my/63349/2/63349_Transdermal%20delivery%20of%20raloxifene%20HCl_SCOPUS.pdf; http://irep.iium.edu.my/63349/13/63349_Transdermal%20delivery%20of%20raloxifene%20HCl_WOS.pdf; http://irep.iium.edu.my/63349/; https://www.sciencedirect.com/science/article/pii/S037851731830125X?via%3Dihub; https://doi.org/10.1016/j.ijpharm.2018.02.044

Raloxifene HCl belongs to a class of selective estrogen receptor modulators (SERMs) which is used for the management of breast cancer. The major problem reported with raloxifene is its poor bioavailability which is only up to 2%. The main objective of the present work was to formulate raloxifene loa...