Sclerostin attenuates the mechanical loading response in trabecular bone

• Main Authors: Khalid, Kamarul Ariffin, Kogawa, Masakagi, Findlay, David M, Atkins, Gerald J
• Format: Conference or Workshop Item
• Language: English
• Published: 2012
• Subjects: QH301 Biology; R Medicine (General); RD701 Orthopedics
• Online Access: http://irep.iium.edu.my/66314/11/66314%20abstract.PDF; http://irep.iium.edu.my/66314/

Osteocytes play a major role in normal bone maintenance and have recently been implicated in a number of conditions that affect bone. Sclerostin is an osteocyte secreted protein, deficiency of which was found to be causative of the high bone mass phenotype in patients with sclerosteosis and van Buch...