Mechanical loading response in trabecular bone is abrogated by sclerostin - A direct demonstration

• Main Authors: Khalid, Kamarul Ariffin, Kogawa, Masakazu, Wijenayaka, Asiri R, Findlay, David M, Atkins, Gerald J
• Format: Conference or Workshop Item
• Language: English; English; English
• Published: Australian Health and Medical Research Council 2012
• Subjects: QH301 Biology; RD701 Orthopedics
• Online Access: http://irep.iium.edu.my/29838/17/29838%20-abstract.PDF; http://irep.iium.edu.my/29838/1/AHMRC_2012_Poster_Kamarul_Final.pdf; http://irep.iium.edu.my/29838/2/AHMRC_2012_Kamarul_Final.pdf; http://irep.iium.edu.my/29838/

Sclerostin is expressed almost exclusively by mature osteocytes in bone. Recent findings from this lab indicate that sclerostin targets pre-osteocytes and osteocytes to regulate bone mineralisation(1), osteoclast activity(2), and, potentially, osteocytic osteolysis(3). Sclerostin expression in vivo...