Direct effect of sclerostin on the mechanical loading response in bovine bone

• Main Authors: Khalid, Kamarul Ariffin, Kogawa, Masakazu, Wijenayaka, Asiri R, Findlay, David M, Atkins, Gerald J
• Format: Conference or Workshop Item
• Language: English
• Published: 2012
• Subjects: QH301 Biology; QP Physiology; R Medicine (General); RD701 Orthopedics
• Online Access: http://irep.iium.edu.my/66161/27/66161%20Direct%20effect%20of%20sclerostin%20on%20the%20mechanical%20loading%20response%20in%20bovine%20bone.PDF; http://irep.iium.edu.my/66161/

Sclerostin is expressed exclusively by mature osteocytes in bone. Our recent findings indicate that sclerostin targets pre-osteocytes/osteocytes to regulate bone mineralisation(1), osteoclast activity(2), and, potentially, osteocytic osteolysis(3). Sclerostin expression in vivo is associated with th...