Recombinant sclerostin antagonizes effects of ex vivo mechanical loading in trabecular bone and increases osteocyte lacunar size

• Main Authors: Kogawa, M, Khalid, Kamarul Ariffin, Wijenayaka, Asiri R, Ormsby, Renee T, Evdokiou, A, Anderson, Peter H, Findlay, David M, Atkins, Gerald J
• Format: Article
• Language: English; English
• Published: 2018
• Subjects: QH301 Biology; QP Physiology; RD701 Orthopedics
• Online Access: http://irep.iium.edu.my/69488/1/ajpcell.00175.2017.pdf; http://irep.iium.edu.my/69488/7/Scopus%20-%20Document%20details.pdf; http://irep.iium.edu.my/69488/

Sclerostin has emerged as an important regulator of bone mass. We have shown that sclerostin can act by targeting late osteoblasts/osteocytes to inhibit bone mineralization and to upregulate osteocyte expression of catabolic factors, resulting in osteocytic osteolysis. Here we sought to examine the...