Phosphate ‘sensing’ by human bone

• Main Authors: Ito, Nobuaki, Kogawa, Masakagi, Wijenayaka, Asiri, Welldon, Katie J, Khalid, Kamarul Ariffin, Ormsby, Renee T, Atkins, Gerald J, Findlay, David M
• Format: Article
• Language: English; English
• Published: Springer 2011
• Subjects: QH301 Biology; QH426 Genetics; R Medicine (General)
• Online Access: http://irep.iium.edu.my/65044/20/65044-abstract.PDF; http://irep.iium.edu.my/65044/21/65044%20Phosphate%20%E2%80%98sensing%E2%80%99%20in%20human%20bone-poster.pdf; http://irep.iium.edu.my/65044/; https://link.springer.com/article/10.1007/s00198-011-1717-8

Aim: Osteocytes and osteoblasts produce the humoral factor, FGF23, which maintains serum levels of phosphate and 1, 25 dihydroxy vitamin D within the physiological range. This implies the ability to sense the levels of phosphate in blood and interstitial fluid, however there is no phosphate sensing...