Clinicopathological features of homologous recombination deficient epithelial ovarian cancers: sensitivity to PARP inhibitors, platinum and survival

• Main Authors: Mukhophadyay, Asima, Plummer, Elizabeth R, Elattar, Ahmed, San, SooHoo, Uzir, Bisha Fathamah, Quinn, Jennifer E, Edmondson, Richard J, Curtin, Nicola J, Harriet, Aneke, Maxwell, Perry, McCluggage, W Glenn
• Format: Article
• Language: English
• Published: American Association of Cancer Research 2012
• Subjects: RB Pathology; RG Gynecology and obstetrics
• Online Access: http://irep.iium.edu.my/33769/1/33769.pdf; http://irep.iium.edu.my/33769/; http://cancerres.aacrjournals.org/content/early/2012/10/11/0008-5472.CAN-12-0324.abstract

Up to 50% of epithelial ovarian cancers (EOC) display defects in the homologous recombination (HR) pathway. We sought to determine the ramifications of the homologous recombination deficient (HRD) status on the clinicopathological features, chemotherapy response and survival outcomes of EOC patie...