Cover Image

Cox-2 inhibitors from stem bark of Bauhinia rufescens lam. (Fabaceae)

Chemical investigation of the stem bark of Bauhinia rufescens resulted in the isolation of a new cyanoglucoside and menisdaurin from methanol extract and oxepin from petroleum ether extract. The isolated compounds were tested for their anti-inflammatory potentials based on the cyclooxygenase-2 enzym...

Full description

Saved in:
Bibliographic Details
Main Authors: Mohd. Sirat, Hasnah, Muhammad, Aminu
Format: Article
Language:English
Published: 2013
Subjects:
Q Science (General)
Online Access:http://eprints.utm.my/id/eprint/49079/1/HasnahMohdSirat2013_Cox-2inhibitorsfromstembark.pdf
http://eprints.utm.my/id/eprint/49079/
https://www.semanticscholar.org
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.utm.49079
record_format eprints
spelling my.utm.490792018-09-27T04:07:21Z http://eprints.utm.my/id/eprint/49079/ Cox-2 inhibitors from stem bark of Bauhinia rufescens lam. (Fabaceae) Mohd. Sirat, Hasnah Muhammad, Aminu Q Science (General) Chemical investigation of the stem bark of Bauhinia rufescens resulted in the isolation of a new cyanoglucoside and menisdaurin from methanol extract and oxepin from petroleum ether extract. The isolated compounds were tested for their anti-inflammatory potentials based on the cyclooxygenase-2 enzyme (COX-2) model. Cyanoglucoside exhibited the highest activity among the compounds with an inhibition activity of 49.34% at 100 μM (IC50 0.46 μM) compared to the positive control, indomethacin (79.20%, IC50 0.24 μM) 2013 Article PeerReviewed application/pdf en http://eprints.utm.my/id/eprint/49079/1/HasnahMohdSirat2013_Cox-2inhibitorsfromstembark.pdf Mohd. Sirat, Hasnah and Muhammad, Aminu (2013) Cox-2 inhibitors from stem bark of Bauhinia rufescens lam. (Fabaceae). EXCLI Journal, 12 . pp. 824-830. ISSN 1611-2156 https://www.semanticscholar.org
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
language English
topic Q Science (General)
spellingShingle Q Science (General)
Mohd. Sirat, Hasnah
Muhammad, Aminu
Cox-2 inhibitors from stem bark of Bauhinia rufescens lam. (Fabaceae)
description Chemical investigation of the stem bark of Bauhinia rufescens resulted in the isolation of a new cyanoglucoside and menisdaurin from methanol extract and oxepin from petroleum ether extract. The isolated compounds were tested for their anti-inflammatory potentials based on the cyclooxygenase-2 enzyme (COX-2) model. Cyanoglucoside exhibited the highest activity among the compounds with an inhibition activity of 49.34% at 100 μM (IC50 0.46 μM) compared to the positive control, indomethacin (79.20%, IC50 0.24 μM)
format Article
author Mohd. Sirat, Hasnah
Muhammad, Aminu
author_facet Mohd. Sirat, Hasnah
Muhammad, Aminu
author_sort Mohd. Sirat, Hasnah
title Cox-2 inhibitors from stem bark of Bauhinia rufescens lam. (Fabaceae)
title_short Cox-2 inhibitors from stem bark of Bauhinia rufescens lam. (Fabaceae)
title_full Cox-2 inhibitors from stem bark of Bauhinia rufescens lam. (Fabaceae)
title_fullStr Cox-2 inhibitors from stem bark of Bauhinia rufescens lam. (Fabaceae)
title_full_unstemmed Cox-2 inhibitors from stem bark of Bauhinia rufescens lam. (Fabaceae)
title_sort cox-2 inhibitors from stem bark of bauhinia rufescens lam. (fabaceae)
publishDate 2013
url http://eprints.utm.my/id/eprint/49079/1/HasnahMohdSirat2013_Cox-2inhibitorsfromstembark.pdf
http://eprints.utm.my/id/eprint/49079/
https://www.semanticscholar.org
_version_ 1643652713915875328
score 13.187197

Similar Items