Cox-2 inhibitors from stem bark of Bauhinia rufescens lam. (Fabaceae)
Chemical investigation of the stem bark of Bauhinia rufescens resulted in the isolation of a new cyanoglucoside and menisdaurin from methanol extract and oxepin from petroleum ether extract. The isolated compounds were tested for their anti-inflammatory potentials based on the cyclooxygenase-2 enzym...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
2013
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| Subjects: | |
| Online Access: | http://eprints.utm.my/id/eprint/49079/1/HasnahMohdSirat2013_Cox-2inhibitorsfromstembark.pdf http://eprints.utm.my/id/eprint/49079/ https://www.semanticscholar.org |
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| Summary: | Chemical investigation of the stem bark of Bauhinia rufescens resulted in the isolation of a new cyanoglucoside and menisdaurin from methanol extract and oxepin from petroleum ether extract. The isolated compounds were tested for their anti-inflammatory potentials based on the cyclooxygenase-2 enzyme (COX-2) model. Cyanoglucoside exhibited the highest activity among the compounds with an inhibition activity of 49.34% at 100 μM (IC50 0.46 μM) compared to the positive control, indomethacin (79.20%, IC50 0.24 μM) |
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