Identification of potential riboflavin synthase inhibitors by virtual screening and molecular dynamics simulation studies

• Main Authors: Mohamad Aris, Sayangku Nor Ariati, Abdul Rahman, Mohd Zulhilmi, Raja Abd Rahman, Raja Noor Zaliha, Mohamad Ali, Mohd Shukuri, Salleh, Abu Bakar, Teo, Chian Ying, Leow, Adam Thean Chor
• Format: Article
• Language: English
• Published: Elsevier 2021
• Online Access: http://psasir.upm.edu.my/id/eprint/97605/1/ABSTRACT.pdf; http://psasir.upm.edu.my/id/eprint/97605/; https://www.sciencedirect.com/science/article/pii/S1018364720303839

Riboflavin synthase is an important enzyme catalyzing the last step of riboflavin biosynthesis in microorganisms. Due to the absolute dependency of the microbes to this biosynthetic pathway coupled with its nonexistence in humans, riboflavin synthase (RiS) is considered as a prospective drug target....