Unraveling the crystal structure of Leptospira kmetyi riboflavin synthase and computational analyses for potential development of new antibacterials

• Main Authors: Mohamad Aris, Sayangku Nor Ariati, Raja Abd Rahman, Raja Noor Zaliha, Mohamad Ali, Mohd Shukuri, Jonet, Mohd Anuar, Taiki, Motomura, Muhd Noor, Noor Dina, Mohd Shariff, Fairolniza, Kai-Cheng, Hsu, Thean, Chor Leow
• Format: Article
• Published: Elsevier BV 2022
• Online Access: http://psasir.upm.edu.my/id/eprint/102542/; https://www.sciencedirect.com/science/article/pii/S0022286022010766

Over the last decade, an escalating number of reported cases of leptospirosis in Malaysia has resulted in a significant number of deaths. Leptospirosis is caused by Leptospira sp., which is disseminated by soil and water. Due to the absolute dependence of microbes on this biosynthesis pathway couple...