Diarylpentanoid (1,5-bis(4-hydroxy-3-methoxyphenyl)-1,4-pentadiene-3-one) (MS13) exhibits anti-proliferative, apoptosis induction and anti-migration properties on androgen-independent human prostate cancer by targeting cell cycle-apoptosis and PI3K signalling pathways

• Main Authors: Abd Wahab, Nurul Azwa, Abas, Faridah, Othman, Iekhsan, Naidu, Rakesh
• Format: Article
• Language: English
• Published: Frontiers Media 2021
• Online Access: http://psasir.upm.edu.my/id/eprint/96718/1/ABSTRACT.pdf; http://psasir.upm.edu.my/id/eprint/96718/; https://www.frontiersin.org/articles/10.3389/fphar.2021.707335/full

Diarylpentanoids exhibit a high degree of anti-cancer activity and stability in vitro over curcumin in prostate cancer cells. Hence, this study aims to investigate the effects of a diarylpentanoid, 1,5-bis(4-hydroxy-3-methoxyphenyl)-1,4-pentadiene-3-one (MS13) on cytotoxicity, anti-proliferative, ap...