Alpha-tomatine synergises with paclitaxel to enhance apoptosis of androgen-independent human prostate cancer PC-3 cells in vitro and in vivo

• Main Authors: Lee, Sui-Ting, Wong, Pooi Fong, Hooper, J.D., Mustafa, Mohd Rais
• Format: Article
• Language: English
• Published: 2013
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/8531/1/1-s2.0-S0944711313002468-main.pdf; http://eprints.um.edu.my/8531/; http://www.sciencedirect.com/science/article/pii/S0944711313002468

Alpha (α)-tomatine, a major saponin found in tomato has been shown to inhibit the growth of androgen-independent prostate cancer PC-3 cells. The effects of α-tomatine in combination with the chemotherapeutic agent paclitaxel against PC-3 cells were investigated in the present study. Combined treat...