mRNA expression of Somatostatin receptors 1-5 in MCF7 and MDA-MB231 breast cancer cells
Background: Breast cancer is one of the most common types of cancer and heterogeneous disease. Somatostatin receptors (SSTRs) are expressed in normal and tumour tissues including breast cancer cells. Objective: The aim of this study to evaluate the expression of SSTRs subtypes 1 – 5 in MCF7 and MD...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Published: |
Radiance Bahu - Uddeshiya Sanstha
2021
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| Online Access: | http://psasir.upm.edu.my/id/eprint/94283/ https://ijcrr.com/abstract.php?article_id=3497 |
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| Summary: | Background: Breast cancer is one of the most common types of cancer and heterogeneous disease. Somatostatin receptors
(SSTRs) are expressed in normal and tumour tissues including breast cancer cells.
Objective: The aim of this study to evaluate the expression of SSTRs subtypes 1 – 5 in MCF7 and MDA-MB231 human breast
cancer cell lines and compare the levels between two cells.
Methods: The detection of mRNA expression levels of SSTRs in MCF7 and MDA-MB231 was performed using quantitativepolymerase chain reaction (qPCR).
Results: SSTR1, 2, 3 and 4 mRNA levels were significantly higher in MDA-MB-231 about MCF-7. The expression of SSTR 4
mRNA was highest in MDA-MB231 and MCF-7 cell lines, however, SSTR3 mRNA was least expressed in both cell lines.
Conclusion: SSTRs subtypes (1 – 5) were expressed in both MDA-MB231 and MCF7 cells. However, the levels of expression
differ between both cell lines. |
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