Ts1Cje mouse model for Down syndrome exhibits motor function deficit; the potential role of MRFS and peripheral nervous system

• Main Authors: Bala, Usman, Othman, Fauziah, Lai, Mei I., Ling, King Hwa, Cheah, Pike See
• Format: Conference or Workshop Item
• Language: English
• Published: 2015
• Online Access: http://psasir.upm.edu.my/id/eprint/75605/1/Ts1Cje%20mouse%20model%20for%20Down%20syndrome%20exhibits%20motor%20function%20deficit%3B%20the%20potential%20role%20of%20MRFS%20and%20peripheral%20nervous%20system.pdf; http://psasir.upm.edu.my/id/eprint/75605/

Introduction: Down syndrome (DS) is a chromosomal abnormality caused by presence of extra-copy of human chromosome 21. Motor dysfunction due to hypotonia is commonly seen in DS individuals and its etiology is still unknown. In this study, we employed the Ts1Cje, a mouse model for DS to investigate t...