The TRPM2 channel nexus from oxidative damage to Alzheimers pathologies: an emerging novel intervention target for age-related dementia

• Main Authors: Jiang, Lin-Hua, Li, Xin, Syed Mortadza, Sharifah Alawieyah, Lovatt, Megan, Yang, Wei
• Format: Article
• Language: English
• Published: Elsevier 2018
• Online Access: http://psasir.upm.edu.my/id/eprint/74277/1/The%20TRPM2%20channel%20nexus%20from%20oxidative%20damage%20to%20Alzheimers%20pathologies.pdf; http://psasir.upm.edu.my/id/eprint/74277/

Alzheimer's disease (AD), an age-related neurodegenerative condition, is the most common cause of dementia among the elder people, but currently there is no treatment. A number of putative pathogenic events, particularly amyloid β peptide (Aβ) accumulation, are believed to be early triggers tha...