TRPM2 channel in microglia as a new player in neuroinflammation associated with a spectrum of central nervous system pathologies

• Main Authors: Malko, Philippa, Syed Mortadza, Sharifah Alawieyah, McWilliam, Joseph, Jiang, Lin Hua
• Format: Article
• Language: English
• Published: Frontiers Media 2019
• Online Access: http://psasir.upm.edu.my/id/eprint/82443/1/TRPM2%20channel%20in%20microglia%20as%20a%20new%20player%20in%20neuroinflammation%20associated%20with%20a%20spectrum%20of%20central%20nervous%20system%20pathologies.pdf; http://psasir.upm.edu.my/id/eprint/82443/; https://www.frontiersin.org/articles/10.3389/fphar.2019.00239/full

Microglial cells in the central nervous system (CNS) are crucial in maintaining a healthy environment for neurons to function properly. However, aberrant microglial cell activation can lead to excessive generation of neurotoxic proinflammatory mediators and neuroinflammation, which represents a cont...