Signalling mechanism in TRPM2-dependent copper- induced HT22 cell death

• Main Authors: Rathakrishnan, Sharani, Hazanol, Iffa Nadhira, Dali, Mohd Haziq Izzazuddin, Sha’fie, Muhammad Syahreel Azhad, Ahmad, Syahida, Alitheen, Noorjahan Banu, Syed Mortadza, Sharifah Alawieyah
• Format: Article
• Published: Hibiscus Publisher 2023
• Online Access: http://psasir.upm.edu.my/id/eprint/110545/; https://journal.hibiscuspublisher.com/index.php/JOBIMB/article/view/836

Copper (Cu) is one of the critical elements needed by the human body. However, this metal can cause cytotoxicity when present in excess amounts. In this study, we used HT22 hippocampus cells to examine the function of the Ca2+-permeable transient receptor melastatin 2 (TRPM2) channel in Cu-induced n...