Antinociceptive activity of methanolic extract of Clinacanthus nutans leaves: possible mechanisms of action involved

• Main Authors: Zakaria, Zainul Amiruddin, Abdul Rahim, Mohammad Hafiz, Roosli, Rushduddin Al Jufri, Mohd Sani, Mohd Hijaz, Omar, Maizatul Hasyima, Mohd Tohid, Siti Farah, Othman, Fezah, Siew, Mooi Ching, Abdul Kadir, Arifah
• Format: Article
• Language: English
• Published: Hindawi 2018
• Online Access: http://psasir.upm.edu.my/id/eprint/73162/1/NUTAN.pdf; http://psasir.upm.edu.my/id/eprint/73162/; https://www.hindawi.com/journals/prm/2018/9536406/

Methanolic extract of Clinacanthus nutans Lindau leaves (MECN) has been proven to possess antinociceptive activity that works via the opioid and NO-dependent/cGMP-independent pathways. In the present study, we aimed to further determine the possible mechanisms of antinociception of MECN using vari...