Antinociceptive activity of petroleum ether fraction obtained from methanolic extract of Clinacanthus nutans leaves involves the activation of opioid receptors and NO-mediated/cGMP-independent pathway

• Main Authors: Zakaria, Zainul Amiruddin, Abdul Rahim, Mohammad Hafiz, Mohd Sani, Mohd Hijaz, Omar, Maizatul Hasyima, Ching, Siew Mooi, Abdul Kadir, Arifah, Ahmed, Qamar Uddin
• Format: Article
• Language: English; English; English
• Published: BioMed Central Ltd 2019
• Subjects: Q Science (General)
• Online Access: http://irep.iium.edu.my/72387/1/72387%20Antinociceptive%20activity%20of%20petroleum%20ether.pdf; http://irep.iium.edu.my/72387/2/72387%20Antinociceptive%20activity%20of%20petroleum%20ether%20SCOPUS.pdf; http://irep.iium.edu.my/72387/13/72387_Antinociceptive%20activity%20of%20petroleum%20ether%20fraction%20obtained%20from%20methanolic%20extract_wos.pdf; http://irep.iium.edu.my/72387/; https://bmccomplementalternmed.biomedcentral.com/track/pdf/10.1186/s12906-019-2486-8

Background Methanol extract (MECN) of Clinacanthus nutans Lindau leaves (family Acanthaceae) demonstrated peripherally and centrally mediated antinociceptive activity via the modulation of opioid/NO-mediated, but cGMP-independent pathway. In the present study, MECN was sequentially partitioned to o...