Antinoceptive activity of methanolic extract of Clinacanthus nutans leaves : possible mechanisms of action involved

• Main Authors: Zakaria, Zainul Amiruddin, Ching, Siew Mooi, Mohd Sani, Mohd Hijaz, Abdul Rahim, Mohammad Hafiz, Roosli, Rushduddin Al Jufri, Othman, Fezah, Md Tohid, Siti Farah, Abdul Kadir, Arifah, Omar, Maizatul Hasyima
• Format: Article
• Language: English
• Published: Hindawi Limited 2018
• Online Access: http://psasir.upm.edu.my/id/eprint/73161/1/NUTANS.pdf; http://psasir.upm.edu.my/id/eprint/73161/; https://www.hindawi.com/journals/prm/2018/9536406/

Methanolic extract of Clinacanthus nutans Lindau leaves (MECN) has been proven to possess antinociceptive activity that works via the opioid and NO-dependent/cGMP-independent pathways. In the present study, we aimed to further determine the possible mechanisms of antinociception of MECN using variou...