Methanol extract of Dicranopteris linearis leaves attenuate pain via the modulation of opioid/NO-mediated pathway

• Main Authors: Zakaria, Zainul Amiruddin, Roosli, Rushduddin Al Jufri, Marmaya, Najihah Hanisah, Omar, Maizatul Hasyima, Basir, Rusliza, Somchit, Muhammad Nazrul
• Format: Article
• Language: English
• Published: MDPI 2020
• Online Access: http://psasir.upm.edu.my/id/eprint/38160/1/38160.pdf; http://psasir.upm.edu.my/id/eprint/38160/; https://www.mdpi.com/2218-273X/10/2/280

Dicranopteris linearis leaf has been reported to exert antinociceptive activity. The present study elucidates the possible mechanisms of antinociception modulated by the methanol extract of D. linearis leaves (MEDL) using various mouse models. The extract (25, 150, and 300 mg/kg) was administered or...