Synthesis and in vitro bioactivity evaluation of new galactose and fructose ester derivatives of 5-aminosalicylic acid

• Main Authors: Yousefi, Samira, Bayat, Saadi, Rahman, Mohd Basyaruddin Abdul, Ibrahim, Zalikha, Abdulmalek, Emilia
• Format: Article
• Language: English
• Published: Wiley 2017
• Online Access: http://psasir.upm.edu.my/id/eprint/63359/1/Synthesis%20and%20in%20vitro%20bioactivity%20evaluation%20of%20new%20galactose%20and%20fructose%20ester%20derivatives%20of%205-aminosalicylic%20acid.pdf; http://psasir.upm.edu.my/id/eprint/63359/; https://onlinelibrary.wiley.com/doi/epdf/10.1002/cbdv.201600362

Inflammatory bowel disease (IBD) is the main risk factor for developing colorectal cancer which is common in patients of all ages. 5-Aminosalicylic acid (5-ASA), structurally relat ed to the salicylates, is highly active in the treatment of IBD with minor side effects. In this study, the synthesis of...