Synthesis and in-vitro bioactivity evaluation of new galactose and fructose ester derivatives of 5-aminosalicylic acid

• Main Authors: Yousefi, Samira, Bayat, Saadi, Abdul Rahman, Mohd Basyaruddin, Ibrahim, Zalikha, Abdulmalek, Emilia
• Format: Article
• Language: English
• Published: Wiley-VHCA AG, Zurich, Switzerland 2017
• Subjects: QD Chemistry
• Online Access: http://irep.iium.edu.my/57352/1/Samira%20et%20al%20%282017%29.pdf; http://irep.iium.edu.my/57352/; http://onlinelibrary.wiley.com/doi/10.1002/cbdv.201600362/full

Inflammatory bowel disease (IBD) is the main risk factor for developing colorectal cancer which is common in patients of all ages. 5-aminosalicylic acid (5-ASA), structurally related to the salicylates, is highly active in the treatment of IBD with minor side effects. In this study, the synthesis of...