In vivo study of tetraprenyltoluquinone, an anticancer compounds from Garcinia cowa Roxb

• Main Authors: Wahyuni, Fatma Sri, Lim, Siang Hui, Stanslas, Johnson, Lajis, Nordin, Hamidi, Dachriyanus
• Format: Article
• Language: English
• Published: Wolters Kluwer - Medknow Publications and Media 2017
• Online Access: http://psasir.upm.edu.my/id/eprint/62141/1/In%20vivo%20study%20of%20tetraprenyltoluquinone%2C%20an%20anticancer%20compounds%20from%20Garcinia%20cowa%20Roxb.pdf; http://psasir.upm.edu.my/id/eprint/62141/; http://www.jyoungpharm.org/article/1003

Objective: To investigate the in vivo antitumor effect of TPTQ against H-460 lung cancer cell lines in nude mice. Materials and Methods: Female nude mice bearing H-460 tumor at size approximately 5 mm in diameter were treated with a single intraperitoneal dose 800 mg/kg of TPTQ. The vehicletreated (10% tween 80) animals were used as control group. The tumor size and mice body weight were measured for 14 days. Results: Single treatment of 800 mg/kg of TPTQ displayed moderate antitumor activity against H-460 tumor xenografts as compared with vehicle-treated control. The mean time to reach RTV of 4 for vehicle-treated control group was 4.5 days whereas for TPTQ-treated (800 mg/kg) group was 9.5 days. Conclusion: The results showed that TPTQ slowed the tumor growth by 5 days. Thus, TPTQ may be considered as a promising compound in cancer chemotherapy.