SRJ09, a promising anticancer drug lead: elucidation of mechanisms of antiproliferative and apoptogenic effects and assessment of in vivo antitumor efficacy

• Main Authors: Wong, Charng Choon, Lim, Siang Hui, Sagineedu, Sreenivasa Rao, Lajis, Nordin, Stanslas, Johnson
• Format: Article
• Language: English
• Published: Elsevier 2016
• Online Access: http://psasir.upm.edu.my/id/eprint/53871/1/SRJ09%2C%20a%20promising%20anticancer%20drug%20lead.pdf; http://psasir.upm.edu.my/id/eprint/53871/; https://www.sciencedirect.com/science/article/pii/S1043661816000542

SRJ09 (3,19-(2-bromobenzylidene)andrographolide), a semisynthetic andrographolide (AGP) derivative, was shown to induce G1 cell cycle arrest and eventually apoptosis in breast and colon cancer cell lines. The present investigation was carried out to elucidate the mechanisms cell cycle arrest and apo...