Characterisation, in-vitro and in-vivo evaluation of valproic acid-loaded nanoemulsion for improved brain bioavailability

• Main Authors: Tan, Suk Fei, Kirby, Brian P., Stanslas, Johnson, Basri, Hamidon
• Format: Article
• Language: English
• Published: John Wiley & Sons 2017
• Online Access: http://psasir.upm.edu.my/id/eprint/61082/1/Characterisation%2C%20in-vitro%20and%20in-vivo%20evaluation%20of%20valproic%20acid-loaded%20nanoemulsion%20for%20improved%20brain%20bioavailability.pdf; http://psasir.upm.edu.my/id/eprint/61082/; https://onlinelibrary.wiley.com/doi/full/10.1111/jphp.12800

OBJECTIVE: This study was aimed to investigate the potential of formulated valproic acid-encapsulated nanoemulsion (VANE) to improve the brain bioavailability of valproic acid (VPA). METHODS: Valproic acid-encapsulated nanoemulsions were formulated and physically characterised (osmolarity, viscosity...