Nanoemulsion-based parenteral drug delivery system of carbamazepine: preparation, characterization, stability evaluation and blood-brain pharmacokinetics

• Main Authors: Tan, Sim Ling, Stanslas, Johnson, Basri, Mahiran, Abedi Karjiban, Roghayeh, Kirby, Brian P., Sani, Dahiru, Basri, Hamidon
• Format: Article
• Language: English
• Published: Bentham Science Publishers 2015
• Online Access: http://psasir.upm.edu.my/id/eprint/45574/1/Nanoemulsion-based%20parenteral%20drug%20delivery%20system%20.pdf; http://psasir.upm.edu.my/id/eprint/45574/; https://pubmed.ncbi.nlm.nih.gov/26324229/

Carbamzepine (CBZ) was encapsulated in a parenteral oil-in-water nanoemulsion, in an attempt to improve its bioavailability. The particle size, polydispersity index and zeta potential were measured using dynamic light scattering. Other parameters such as pH, osmolality, viscosity, drug loading effic...