A ruthenium polypyridyl intercalator stalls DNA replication forks, radiosensitizes human cancer cells and is enhanced by Chk1 inhibition
Ruthenium(II) polypyridyl complexes can intercalate DNA with high affinity and prevent cell proliferation; however, the direct impact of ruthenium-based intercalation on cellular DNA replication remains unknown. Here we show the multi-intercalator [Ru(dppz)2(PIP)](2+) (dppz = dipyridophenazine, PIP ...
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Main Authors: | Gill, Martin R., Harun, Siti Norain, Halder, Swagata, Boghozian, Ramon A., Ramadan, Kristijan, Ahmad, Haslina, Vallis, Katherine A. |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2016
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Online Access: | http://psasir.upm.edu.my/id/eprint/54929/1/A%20ruthenium%20polypyridyl%20intercalator%20stalls%20DNA%20replication%20forks%2C%20radiosensitizes%20human%20cancer%20cells%20and%20is%20enhanced%20by%20Chk1%20inhibition.pdf http://psasir.upm.edu.my/id/eprint/54929/ |
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