A ruthenium polypyridyl intercalator stalls DNA replication forks, radiosensitizes human cancer cells and is enhanced by Chk1 inhibition

• Main Authors: Gill, Martin R., Harun, Siti Norain, Halder, Swagata, Boghozian, Ramon A., Ramadan, Kristijan, Ahmad, Haslina, Vallis, Katherine A.
• Format: Article
• Language: English
• Published: Nature Publishing Group 2016
• Online Access: http://psasir.upm.edu.my/id/eprint/54929/1/A%20ruthenium%20polypyridyl%20intercalator%20stalls%20DNA%20replication%20forks%2C%20radiosensitizes%20human%20cancer%20cells%20and%20is%20enhanced%20by%20Chk1%20inhibition.pdf; http://psasir.upm.edu.my/id/eprint/54929/

Ruthenium(II) polypyridyl complexes can intercalate DNA with high affinity and prevent cell proliferation; however, the direct impact of ruthenium-based intercalation on cellular DNA replication remains unknown. Here we show the multi-intercalator [Ru(dppz)2(PIP)](2+) (dppz = dipyridophenazine, PIP ...