Inter-individual variability in propofol pharmacokinetic/pharmacodynamic (PK/PD) model – a sensitivity analysis

• Main Authors: Chang, J. J., Syafiie, S., Raja Ahmad, Raja Mohd Kamil, Lim, T. A.
• Format: Article
• Language: English
• Published: Scholars Academic and Scientific Publisher 2016
• Online Access: http://psasir.upm.edu.my/id/eprint/54599/1/Inter-individual%20variability%20in%20propofol%20pharmacokinetic%2C%20pharmacodynamic%20PK%2C%20PD%20model%20%E2%80%93%20a%20sensitivity%20analysis.pdf; http://psasir.upm.edu.my/id/eprint/54599/; http://saspublisher.com/sjams-411/

Inter-individual variability is a major challenge to guarantee adequate anaesthesia in patients across the population. This variability can occur as a result of patient physiology (e.g. age and weight), variations in the pharmacokinetic (PK) process and differences in the pharmacodynamic (PD) functi...