Three ammonium salts of sulfathiazole: crystallography and anti-microbial assay
The crystal and molecular structures of three ammonium salts derived from sulfathiazole are described. In each case, the anion is in the azanide form, features an intramolecular S←O interaction, and adopts a U-shape. The structures of two cations, [R(HOCH2CH2)NH2]+, namely for R = Me (1) and iPr (2)...
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Main Authors: | , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Walter de Gruyter GmbH
2015
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Online Access: | http://psasir.upm.edu.my/id/eprint/46730/1/Three%20ammonium%20salts%20of%20sulfathiazole%3B%20crystallography%20and%20anti-microbial%20assay.pdf http://psasir.upm.edu.my/id/eprint/46730/ https://www.degruyter.com/document/doi/10.1515/zkri-2014-1830/html?lang=en |
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Summary: | The crystal and molecular structures of three ammonium salts derived from sulfathiazole are described. In each case, the anion is in the azanide form, features an intramolecular S←O interaction, and adopts a U-shape. The structures of two cations, [R(HOCH2CH2)NH2]+, namely for R = Me (1) and iPr (2), are unprecedented in the crystallographic literature. Extensive hydrogen bonding is observed in all crystal structures and leads to a two-dimensional array for 1, and three-dimensional architectures for each of 2 and 3 (R = CH2CH2OH). The salts exhibited anti-microbial activity against a range of Gram-positive and Gram-negative bacteria, and proved bactericidal toward Vibrio parahaemolyticus, but had no advantage over sulfathiazole itself. |
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