Synthesis of thymidine phosphorylase inhibitor based on quinoxaline derivatives and their molecular docking study
We have synthesized quinoxaline analogs (1–25), characterized by 1H-NMR and HREI-MS and evaluated for thymidine phosphorylase inhibition. Among the series, nineteen analogs showed better inhibition when compared with the standard inhibitor 7-Deazaxanthine (IC50 = 38.68 ± 4.42 µM). The most potent co...
Saved in:
Main Authors: | Almandil, Noor Barak, Taha, Muhammad, Farooq, Rai Khalid, Alhibshi, Amani, Ibrahim, Mohamed, Anouar, El Hassane, Gollapalli, Mohammed, Rahim, Fazal, Nawaz, Muhammad, Shah, Syed Adnan Ali, Ahmed, Qamar Uddin, Zakaria, Zainul Amiruddin |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI
2019
|
Online Access: | http://psasir.upm.edu.my/id/eprint/38421/1/38421.pdf http://psasir.upm.edu.my/id/eprint/38421/ https://www.mdpi.com/1420-3049/24/6/1002 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Synthesis of thymidine phosphorylase inhibitor based on quinoxaline derivatives and their molecular docking study
by: Noor Barak, Almandil, et al.
Published: (2019) -
Synthesis of new isoquinoline-base-oxadiazole derivatives as potent inhibitors of thymidine phosphorylase and molecular docking study
by: Zaman, Khalid, et al.
Published: (2019) -
Analysis of Nucleoside Phosphorylase Polymorphism in Capra Hircus
by: Sekaran, M., et al.
Published: (1989) -
Synthesis of chromen-4-one-oxadiazole substituted analogs as potent β-glucuronidase inhibitors
by: Taha, Muhammad, et al.
Published: (2019) -
2-(3-Nitrophenoxy)Quinoxaline
by: Hassan, N.D., et al.
Published: (2010)