Molecular docking studies of selected medicinal drugs as dengue virus-2 protease inhibitors

• Main Authors: Rufaidah Othman,, Rozana Othman,, Aida Baharuddin,, Nagasundara Ramanan Ramakrishnan,, Noorsaadah Abd Rahman,, Rohana Yusof,, Saiful Anuar Karsani,
• Format: Article
• Language: English
• Published: Penerbit Universiti Kebangsaan Malaysia 2017
• Online Access: http://journalarticle.ukm.my/11546/1/25%20Rufaidah%20Othman.pdf; http://journalarticle.ukm.my/11546/; http://www.ukm.my/jsm/english_journals/vol46num10_2017/contentsVol46num10_2017.html

Dengue is a potentially deadly disease with no effective drug. An in silico molecular docking was performed using Autodock 4.2.6 to investigate the molecular interactions between protease inhibitors, comprising antibiotic derivatives namely doxycycline (3), rolitetracycline (5) and a non-steroidal a...