The influence of R substituents in triphenylphosphinegold(I) carbonimidothioates, Ph 3PAu[SC(OR) = NPh] (R = Me, Et and iPr), upon in vitro cytotoxicity against the HT-29 colon cancer cell line and upon apoptotic pathways
The Ph3PAu[SC(OR) = NPh], R = Me (1), Et (2) and iPr (3), compounds are significantly cytotoxic to the HT-29 cancer cell line with1 being the most active. Based on human apoptosis PCR-array analysis, caspase activities, DNA fragmentation, cell apoptotic assays, intracellular reactive oxygen species (...
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Main Authors: | Chien, Ing Yeo, Kah, Kooi Ooi, Md. Akim, Abdah, Ang, Kok Pian, Fairuz, Zainal Abidin, Abdul Halim, Siti Nadiah, Ng, Seik Weng, Seng, Hoi Ling, Tiekink, Edward R.T. |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2013
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Online Access: | http://psasir.upm.edu.my/id/eprint/29788/1/The%20in%EF%AC%82uence%20of%20R%20substituents%20in%20triphenylphosphinegold.pdf http://psasir.upm.edu.my/id/eprint/29788/ |
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