Molecular mechanisms of apoptosis and cell selectivity of zinc dithiocarbamates functionalized with hydroxyethyl substituents

• Main Authors: Tan, Yee Seng, Ooi, Kah Kooi, Ang, Kok Pian, Akim, Abdah Md, Cheah, Yoke Kqueen, Halim, Siti Nadiah Abdul, Seng, Hoi Ling, Tiekink, Edward R.T.
• Format: Article
• Published: Elsevier 2015
• Subjects: Q Science (General); QD Chemistry
• Online Access: http://eprints.um.edu.my/19602/; http://dx.doi.org/10.1016/j.jinorgbio.2015.06.009

In the solid state each of three binuclear zinc dithiocarbamates bearing hydroxyethyl groups, {Zn[S2CN(R)CH2CH2OH]2}2 for R = iPr (1), CH2CH2OH (2), and Me (3), and an all alkyl species, [Zn(S2CNEt2)2]2 (4), features a centrosymmetric {ZnSCS}2 core with a step topology; both 1 and 3 were isolated as...