Potential of dihydropyrimidine dehydrogenase genotypes in personalizing 5-fluorouracil therapy among colorectal cancer patients
BACKGROUND: Dihydropyrimidine dehydrogenase (DPD) is a pyrimidine catabolic enzyme involved in the initial and rate-limiting step of the catabolic pathway of toxic metabolites of 5-fluorouracil (5-FU). Several studies have reported that deficiency of DPD and polymorphisms of its gene are related to...
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Main Authors: | , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Lippincott Williams & Wilkins
2013
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Online Access: | http://psasir.upm.edu.my/id/eprint/29679/1/Potential%20of%20dihydropyrimidine%20dehydrogenase%20genotypes%20in%20personalizing%205.pdf http://psasir.upm.edu.my/id/eprint/29679/ |
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