Potential of dihydropyrimidine dehydrogenase genotypes in personalizing 5-fluorouracil therapy among colorectal cancer patients

• Main Authors: Teh, Lay Kek, Hamzah, Sharina, Hashim, Hazwanie, Bannur, Zakaria, Zakaria, Zainul Amiruddin, Hasbullani, Zakaria, Kwong, John Siew Shia, Fijeraid, Henry, Md Nor, Azmid, Mohd Zailani,, Ramasamy, Prabu, Ngow, Harris, Sood, Suneet, Salleh, Mohd Zaki
• Format: Article
• Language: English
• Published: Lippincott Williams & Wilkins 2013
• Online Access: http://psasir.upm.edu.my/id/eprint/29679/1/Potential%20of%20dihydropyrimidine%20dehydrogenase%20genotypes%20in%20personalizing%205.pdf; http://psasir.upm.edu.my/id/eprint/29679/

BACKGROUND: Dihydropyrimidine dehydrogenase (DPD) is a pyrimidine catabolic enzyme involved in the initial and rate-limiting step of the catabolic pathway of toxic metabolites of 5-fluorouracil (5-FU). Several studies have reported that deficiency of DPD and polymorphisms of its gene are related to...