Effects of CXCR4 siRNA/dextran-spermine nanoparticles on CXCR4 expression and serum LDH levels in a mouse model of colorectal cancer metastasis to the liver.

• Main Authors: Abedini, Fatemeh, Ismail, Maznah, Hosseinkhani, Hossein, Tengku Ibrahim, Tengku Azmi, Omar, Abdul Rahman, Chong, Pei Pei, Bejo, Mohd Hair, Domb, Abraham J.
• Format: Article
• Language: English; English
• Published: 2011
• Online Access: http://psasir.upm.edu.my/id/eprint/25377/1/Effects%20of%20CXCR4%20siRNA.pdf; http://psasir.upm.edu.my/id/eprint/25377/

Liver metastasis is the main cause of mortality related to colorectal cancer. CXCR4 is necessary for the outgrowth of colon cancer micrometastases. In oncology, it has been demonstrated that several human tumors release lactate dehydrogenase (LDH) into the circulation. CXCR4 gene expression and seru...