Gene transfer into the lung by nanoparticle dextran-spermine/plasmid DNA complexes.

• Main Authors: Abdullah, Syahrilnizam, Wai Yeng, Wendy-Yeo, Hosseinkhani, Hossein, Hosseinkhani, Mohsen, Masrawa, Ehab, Ramasamy, Rajesh, Rosli, Rozita, Abdul Rahman, Sabariah, Domb, Abraham J.
• Format: Article
• Language: English; English
• Published: Hindawi Publishing Corporation 2010
• Online Access: http://psasir.upm.edu.my/id/eprint/14867/1/Gene%20transfer%20into%20the%20lung%20by%20nanoparticle%20dextran.pdf; http://psasir.upm.edu.my/id/eprint/14867/; http://www.hindawi.com/

A novel cationic polymer, dextran-spermine (D-SPM), has been found to mediate gene expression in a wide variety of cell lines and in vivo through systemic delivery. Here, we extended the observations by determining the optimal conditions for gene expression of D-SPM/plasmid DNA (D-SPM/pDNA) in cel...