Safety profile of dextran-spermine gene delivery vector in mouse lungs

• Main Authors: Yeo, Wendy Wai Yeng, Hosseinkhani, Hossein, Abdul Rahman, Sabariah, Rosli, Rozita, Domb, Abraham J., Abdullah, Syahrilnizam
• Format: Article
• Language: English
• Published: American Scientific Publishers 2014
• Online Access: http://psasir.upm.edu.my/id/eprint/29784/1/Safety%20profile%20of%20dextran%20spermine%20gene%20delivery%20vector%20in%20mouse%20lungs.pdf; http://psasir.upm.edu.my/id/eprint/29784/

A nano-sized polymer, dextran-spermine (D-SPM), was shown to have the capacity to deliver gene to the lung of mouse via intranasal route. In this study, assessments on the safety profile of D-SPM were performed to complement the gene expression results. African green monkey kidney fibroblast (COS-7)...