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Yeast Glycogen Synthase Kinase-3 Pathway Inhibitors from an Organic Extract of Streptomyces sp.

Investigation of a microbial fermentation organic extract of Streptomyces sp. H7667 led to the isolation of three new imides, 3-[(5E)-5-methyl-4-oxo-2-hydroxy-5-octenyl glutarimide (1), 2-amino-N-2′-(phenylacetyl)propanimide (5), and 2-amino-N-(2′-(cyclohex-2′′-enyl)acetyl)acetimide (6), and one ne...

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Main Authors: Cheenpracha, Sarot, Hui, Zhang, Mar, Annie M. N., Foss, Adam P., Sek, Hin Foo, Ngit, Shin Lai, Jap, Meng Jee, Heng, Fong Seow, Coy, Choke Ho, Leng, Chee Chang
Format: Article
Language:English
English
Published: American Society of Pharmacognosy & American Chemical Society 2009
Online Access:http://psasir.upm.edu.my/id/eprint/17669/1/Yeast%20Glycogen%20Synthase%20Kinase.pdf
http://psasir.upm.edu.my/id/eprint/17669/
http://pubs.acs.org/toc/jnprdf/72/8
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spelling my.upm.eprints.176692015-11-03T07:41:07Z http://psasir.upm.edu.my/id/eprint/17669/ Yeast Glycogen Synthase Kinase-3 Pathway Inhibitors from an Organic Extract of Streptomyces sp. Cheenpracha, Sarot Hui, Zhang Mar, Annie M. N. Foss, Adam P. Sek, Hin Foo Ngit, Shin Lai Jap, Meng Jee Heng, Fong Seow Coy, Choke Ho Leng, Chee Chang Investigation of a microbial fermentation organic extract of Streptomyces sp. H7667 led to the isolation of three new imides, 3-[(5E)-5-methyl-4-oxo-2-hydroxy-5-octenyl glutarimide (1), 2-amino-N-2′-(phenylacetyl)propanimide (5), and 2-amino-N-(2′-(cyclohex-2′′-enyl)acetyl)acetimide (6), and one new isoflavonoid glycoside, 6-O-methyl-7-O-Rrhamnopyranosyldaidzein (7), along with four known compounds. Their structures were elucidated by HRESIMS, 1H and 13C NMR, COSY, HMQC, HMBC, and NOESY spectra. Compounds 1-8 were evaluated for their inhibitory activities in the yeast glycogen synthase kinase-3 assay. American Society of Pharmacognosy & American Chemical Society 2009-11-08 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/17669/1/Yeast%20Glycogen%20Synthase%20Kinase.pdf Cheenpracha, Sarot and Hui, Zhang and Mar, Annie M. N. and Foss, Adam P. and Sek, Hin Foo and Ngit, Shin Lai and Jap, Meng Jee and Heng, Fong Seow and Coy, Choke Ho and Leng, Chee Chang (2009) Yeast Glycogen Synthase Kinase-3 Pathway Inhibitors from an Organic Extract of Streptomyces sp. Journal of Natural Products, 72 (8). pp. 1520-1523. ISSN 0163-3864 & Online ISSN: 1520-6025 http://pubs.acs.org/toc/jnprdf/72/8 10.1021/np900163f English
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
English
description Investigation of a microbial fermentation organic extract of Streptomyces sp. H7667 led to the isolation of three new imides, 3-[(5E)-5-methyl-4-oxo-2-hydroxy-5-octenyl glutarimide (1), 2-amino-N-2′-(phenylacetyl)propanimide (5), and 2-amino-N-(2′-(cyclohex-2′′-enyl)acetyl)acetimide (6), and one new isoflavonoid glycoside, 6-O-methyl-7-O-Rrhamnopyranosyldaidzein (7), along with four known compounds. Their structures were elucidated by HRESIMS, 1H and 13C NMR, COSY, HMQC, HMBC, and NOESY spectra. Compounds 1-8 were evaluated for their inhibitory activities in the yeast glycogen synthase kinase-3 assay.
format Article
author Cheenpracha, Sarot
Hui, Zhang
Mar, Annie M. N.
Foss, Adam P.
Sek, Hin Foo
Ngit, Shin Lai
Jap, Meng Jee
Heng, Fong Seow
Coy, Choke Ho
Leng, Chee Chang
spellingShingle Cheenpracha, Sarot
Hui, Zhang
Mar, Annie M. N.
Foss, Adam P.
Sek, Hin Foo
Ngit, Shin Lai
Jap, Meng Jee
Heng, Fong Seow
Coy, Choke Ho
Leng, Chee Chang
Yeast Glycogen Synthase Kinase-3 Pathway Inhibitors from an Organic Extract of Streptomyces sp.
author_facet Cheenpracha, Sarot
Hui, Zhang
Mar, Annie M. N.
Foss, Adam P.
Sek, Hin Foo
Ngit, Shin Lai
Jap, Meng Jee
Heng, Fong Seow
Coy, Choke Ho
Leng, Chee Chang
author_sort Cheenpracha, Sarot
title Yeast Glycogen Synthase Kinase-3 Pathway Inhibitors from an Organic Extract of Streptomyces sp.
title_short Yeast Glycogen Synthase Kinase-3 Pathway Inhibitors from an Organic Extract of Streptomyces sp.
title_full Yeast Glycogen Synthase Kinase-3 Pathway Inhibitors from an Organic Extract of Streptomyces sp.
title_fullStr Yeast Glycogen Synthase Kinase-3 Pathway Inhibitors from an Organic Extract of Streptomyces sp.
title_full_unstemmed Yeast Glycogen Synthase Kinase-3 Pathway Inhibitors from an Organic Extract of Streptomyces sp.
title_sort yeast glycogen synthase kinase-3 pathway inhibitors from an organic extract of streptomyces sp.
publisher American Society of Pharmacognosy & American Chemical Society
publishDate 2009
url http://psasir.upm.edu.my/id/eprint/17669/1/Yeast%20Glycogen%20Synthase%20Kinase.pdf
http://psasir.upm.edu.my/id/eprint/17669/
http://pubs.acs.org/toc/jnprdf/72/8
_version_ 1643826588723183616
score 13.18916

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