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Yeast Glycogen Synthase Kinase-3 Pathway Inhibitors from an Organic Extract of Streptomyces sp.

Investigation of a microbial fermentation organic extract of Streptomyces sp. H7667 led to the isolation of three new imides, 3-[(5E)-5-methyl-4-oxo-2-hydroxy-5-octenyl glutarimide (1), 2-amino-N-2′-(phenylacetyl)propanimide (5), and 2-amino-N-(2′-(cyclohex-2′′-enyl)acetyl)acetimide (6), and one ne...

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Bibliographic Details
Main Authors: Cheenpracha, Sarot, Hui, Zhang, Mar, Annie M. N., Foss, Adam P., Sek, Hin Foo, Ngit, Shin Lai, Jap, Meng Jee, Heng, Fong Seow, Coy, Choke Ho, Leng, Chee Chang
Format: Article
Language:English
English
Published: American Society of Pharmacognosy & American Chemical Society 2009
Online Access:http://psasir.upm.edu.my/id/eprint/17669/1/Yeast%20Glycogen%20Synthase%20Kinase.pdf
http://psasir.upm.edu.my/id/eprint/17669/
http://pubs.acs.org/toc/jnprdf/72/8
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Summary:Investigation of a microbial fermentation organic extract of Streptomyces sp. H7667 led to the isolation of three new imides, 3-[(5E)-5-methyl-4-oxo-2-hydroxy-5-octenyl glutarimide (1), 2-amino-N-2′-(phenylacetyl)propanimide (5), and 2-amino-N-(2′-(cyclohex-2′′-enyl)acetyl)acetimide (6), and one new isoflavonoid glycoside, 6-O-methyl-7-O-Rrhamnopyranosyldaidzein (7), along with four known compounds. Their structures were elucidated by HRESIMS, 1H and 13C NMR, COSY, HMQC, HMBC, and NOESY spectra. Compounds 1-8 were evaluated for their inhibitory activities in the yeast glycogen synthase kinase-3 assay.

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