Yeast Glycogen Synthase Kinase-3 Pathway Inhibitors from an Organic Extract of Streptomyces sp.

• Main Authors: Cheenpracha, Sarot, Hui, Zhang, Mar, Annie M. N., Foss, Adam P., Sek, Hin Foo, Ngit, Shin Lai, Jap, Meng Jee, Heng, Fong Seow, Coy, Choke Ho, Leng, Chee Chang
• Format: Article
• Language: English; English
• Published: American Society of Pharmacognosy & American Chemical Society 2009
• Online Access: http://psasir.upm.edu.my/id/eprint/17669/1/Yeast%20Glycogen%20Synthase%20Kinase.pdf; http://psasir.upm.edu.my/id/eprint/17669/; http://pubs.acs.org/toc/jnprdf/72/8

Investigation of a microbial fermentation organic extract of Streptomyces sp. H7667 led to the isolation of three new imides, 3-[(5E)-5-methyl-4-oxo-2-hydroxy-5-octenyl glutarimide (1), 2-amino-N-2′-(phenylacetyl)propanimide (5), and 2-amino-N-(2′-(cyclohex-2′′-enyl)acetyl)acetimide (6), and one ne...