Mitochondrial dysfunction in Down Syndrome: from pathology to therapy

• Main Authors: Tan, Kai-Leng, Lee, Han-Chung, Cheah, Pike-See, Ling, King-Hwa
• Format: Article
• Language: English
• Published: Elsevier 2023
• Online Access: http://psasir.upm.edu.my/id/eprint/109511/1/1-s2.0-S0306452222006030-main.pdf; http://psasir.upm.edu.my/id/eprint/109511/; https://linkinghub.elsevier.com/retrieve/pii/S0306452222006030

Mitochondrial dysfunctions have been described in Down syndrome (DS) caused by either partial or full trisomy of chromosome 21 (HSA21). Mitochondria play a crucial role in various vital functions in eukaryotic cells, especially in energy production, calcium homeostasis and programmed cell death. The...