Structural interpretations of a flexible cold-active AMS8 lipase by combining small-angle X-ray scattering and molecular dynamics simulation (SAXS-MD)

• Main Authors: Yaacob, Norhayati, Kamonsutthipaijit, Nuntaporn, Soontaranon, Siriwat, Thean, Adam Chor Leow, Raja Abd Rahman, Raja Noor Zaliha, Mohamad Ali, Mohd Shukuri
• Format: Article
• Published: Elsevier 2022
• Online Access: http://psasir.upm.edu.my/id/eprint/103319/; https://www.sciencedirect.com/science/article/pii/S0141813022018487

Determining structure of highly flexible protein with multiple conformations can be challenging. This paper aims to combine molecular dynamics (MD) and small angle X-ray diffraction (SAX) techniques as a solution to overcome issues related to protein conformation in hardly crystallized protein. Base...